| Target: |
TNF alpha (Tumor necrosis factor alpha (TNF-α)) |
| Reactivity: |
Rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This TNF alpha antibody is un-conjugated |
| Application: |
Blocking antibody (Inhibition), ELISA, western blotting (WB) |
| Purification: |
Purified |
| Immunogen: |
TNF alpha antibody was raised in rabbit using highly pure recombinant rat TNF-alpha as the immunogen. |
| Format: |
Lyophilized |
| Concentration: |
Lot specific |
| Reconstitution: |
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. |
| Buffer: |
Lyophilized from PBS, pH7.2. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store at - 20°C until reconstitution. Following reconstitution product may be stored at 4°C in the short term. For long term storage aliquot and freeze at - 20°C. |
| Alternative Name: |
TNF alpha |
| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
TNF-alpha, a versatile pro-inflammatory cytokine, is secreted by diverse cell types such as adipocytes, activated monocytes, macrophages, B cells, T cells, and fibroblasts. It falls under the TNF family of ligands and operates via two receptors, TNFR1 and TNFR2. This cytokine exhibits cytotoxic effects on numerous tumor cells and is crucial in orchestrating the immune response against bacterial infections. Additionally, TNF-alpha contributes to the development of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. |
| Molecular Weight: |
17.3 kDa (predicted detection band MW) |
