Small Molecule Drug Discovery
Small molecule drug discovery is a crucial aspect of drug research and development, aimed at identifying and developing effective therapeutic compounds for various diseases. Alta Stomatology is an oral disease drug R&D company dedicated to improving the health of millions of individuals suffering from various oral conditions. Our mission is to discover effective small molecule drugs that target specific oral diseases, we can provide you with high-quality small molecule drug discovery services for oral diseases, including target discovery & validation, hit to lead, lead compound optimization, and candidate selection. If you have any needs, please feel free to contact us.
Our Services
Target Discovery & Validation
The initial step in Small Molecule Drug Discovery involves the identification and validation of novel drug targets specific to oral diseases. Alta Stomatology employs advanced techniques such as genomics, proteomics, and bioinformatics to identify potential targets. Once identified, these targets undergo rigorous validation to ensure their relevance and feasibility for therapeutic intervention.
Hit to Lead
At Alta Stomatology, our experienced research and development team selects the most promising series of compounds through limited structure-activity relationship (SAR) studies in the hit-to-lead stage. We also conduct early assessments of in vitro ADMET properties to identify attractive compounds and ensure their entry into the lead compound optimization phase.
Lead Compound Optimization
Alta Stomatology can synthesize and characterize identified lead compounds. Additionally, we can employ functional group manipulation, structure-activity relationship-directed optimization, and natural template-based pharmacophore-guided design to enhance drug potency, selectivity, and pharmacokinetic properties, ensuring optimal performance in the early stages of drug discovery.
Candidate Selection
The final stage involves the selection of the most promising lead compounds, known as candidate drugs, for further development and preclinical studies. Alta Stomatology carefully evaluates the candidates based on various criteria, including their efficacy, safety, pharmacokinetic properties, and potential for commercialization. This selection process is crucial in ensuring the identification of drug candidates with the highest likelihood of success in clinical trials.
Methods of Small Molecule Drug Discovery
Small molecule drug discovery employs a multidisciplinary approach, integrating various scientific fields and methodologies. Some of the key methods we utilize include:
|
High-throughput screening (HTS) |
Virtual Screening |
| Structure-based drug design (SBDD) |
Fragment-based drug design (FBDD) |
| Molecular glue technology |
Proteolysis-targeting chimeras |
Why Choose Alta Stomatology?
- Powerful target validation platform: We have an advanced information platform for target validation, and our R&D team has extensive experience in target validation. We can help clients evaluate the developability of targets, ensuring that clients choose appropriate targets and laying a solid foundation for drug discovery for oral diseases.
- Efficient targeted compound discovery: With the help of computer-aided drug screening and commercially available compound libraries, we can assist clients in rapidly discovering compounds with targeted effects, thereby reducing the cost of early-stage drug discovery for oral diseases and greatly shortening the development cycle.
- Sharp compound design capability: Our team has extensive experience in organic chemistry and medicinal chemistry design, and can quickly find molecules with good drug-like properties during the drug discovery process, greatly improving development efficiency.
- Rapid chemical synthesis capability: Our experienced synthetic chemists can efficiently and quickly synthesize small molecule compounds, accelerating the drug discovery process and further shortening the entire development cycle.
For research use only. Not
intended for any clinical use.
