2-1-1-green-tea-extract-1

TNF Alpha Polyclonal Antibody (AA 78-234) (Sheep)

Cat. No.:	SPODRP00708
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Product Details

Target:	TNF alpha (Tumor necrosis factor alpha (TNF-α))
Binding Specificity:	AA 78-234
Reactivity:	Sheep
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	This TNF alpha antibody is un-conjugated
Application:	ELISA, western blotting (WB)
Cross-Reactivity:	Sheep
Purification:	> 95%, protein G purified.
Immunogen:	Recombinant sheep tumor necrosis factor protein (78-234AA).
Isotype:	IgG
Format:	Liquid
Buffer:	Preservative: 0.03% proclin 300. Constituents: 50% glycerol, 0.01 M PBS, PH7.4.
Precaution of Use:	This product contains a poisonous and hazardous substance which should be handled by trained staff only.
Handling Advice:	Avoid repeated freeze.
Storage:	- 20°C, - 80°C
Storage Comment:	Upon receipt, store at - 20°C or - 80°C.
Alternative Name:	TNF alpha
Synonyms:	DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa.
Background:	This cytokine binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. Primarily released by macrophages, it prompts cell death in specific tumor cell lines. Known for its potent pyrogenic effects, it induces fever directly or by triggering interleukin-1 secretion and is associated with cachexia induction. Moreover, it can stimulate cell proliferation and drive cell differentiation under specific circumstances. Interestingly, the TNF intracellular domain (ICD) variant stimulates IL12 production in dendritic cells.

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