| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
This gene encodes a versatile proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. Primarily secreted by macrophages, it exerts its effects through receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. Involved in regulating diverse biological processes such as cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation, this cytokine is implicated in various diseases including autoimmune diseases, insulin resistance, and cancer. |
