| Target: |
TNF alpha (Tumor necrosis factor alpha (TNF-α)) |
| Reactivity: |
Human, pig |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Conjugate: |
This TNF alpha antibody is conjugated to PE |
| Application: |
ELISA, flow cytometry (FACS), functional studies (Func), immunocytochemistry (ICC), immunohistochemistry (frozen sections) (IHC (fro)) |
| Specificity: |
The mouse monoclonal antibody MAb11 recognizes human 17-26 kDa cytokine TNF-alpha. |
| Immunogen: |
Recombinant human TNF-alpha |
| Clone: |
MAb11 |
| Isotype: |
IgG1 |
| Buffer: |
The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid prolonged exposure to light. |
| Storage: |
4°C |
| Storage Comment: |
Store in the dark at 2 - 8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Alternative Name: |
TNF alpha |
| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
TNF-alpha is a cytokine generated by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells, and various transformed cells. It exists in two forms: a 17 kDa free molecule and a 26 kDa membrane-bound protein. TNF-alpha readily forms stable trimers and other multimeric complexes. Within the immune system, it plays a crucial regulatory role, exhibiting cytolytic and cytostatic effects on numerous tumor cells, promoting fibroblast proliferation, and enhancing neutrophil chemotaxis and phagocytosis. |
