| Target: |
TNF alpha (Tumor necrosis factor alpha (TNF-α)) |
| Reactivity: |
Human |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Conjugate: |
This TNF alpha antibody is un-conjugated |
| Application: |
Functional studies (Func), enzyme immunoassay (EIA), western blotting (WB) |
| Specificity: |
This antibody recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha). |
| Purification: |
Affinity chromatography |
| Immunogen: |
Human TNF |
| Clone: |
MAb1 |
| Isotype: |
IgG1 |
| Buffer: |
PBS, pH7.4, 0.09% sodium azide. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Storage: |
4°C |
| Storage Comment: |
Store the antibody undiluted at 2 - 8°C. |
| Alternative Name: |
Tumor necrosis factor alpha |
| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
TNF-alpha, a cytokine generated by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells, and various transformed cells, manifests in two forms: a 17 kDa unbound molecule or a 26 kDa membrane protein. It readily assembles into stable trimers and other multimeric structures. Within the immune system, TNF-alpha serves as a vital regulator, exhibiting cytolytic and cytostatic effects on numerous tumor cells, promoting fibroblast proliferation, and facilitating neutrophil chemotaxis and phagocytosis. |
