| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
Monoclonal antibody 52B83 targets tumor necrosis factor-alpha (TNF-alpha), a 17 kDa protein that forms homotrimeric structures. TNF-alpha interacts with two types of receptors, I and II, leading to receptor cross-linking and signal transduction, each with distinct intracellular signaling pathways. Originally known for its cytotoxic effects on tumor cells, TNF-alpha induces tumor necrosis in vivo and exhibits cytolytic activity against tumor cells in vitro. Additionally, it serves as a key mediator in numerous inflammatory and immunological processes, inducible by various microbial products and cytokines, resulting in the expression of diverse cytokines. |
