| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
Monoclonal antibody 5N targets TNF-alpha, a 17 KD protein with significant roles in inflammation and metabolism. Initially identified for its cytotoxic effects on tumor cells, TNF-alpha also plays a pivotal role in shock induced by gram-negative microorganisms and various inflammatory and immunological processes. TNF-alpha signals through two receptors, TNF-receptors I and II, each triggering distinct intracellular pathways. Antibody 5N interacts with TNF-alpha across multiple primate species but not pig-tail macaques, with reduced affinity for bovine and canine TNF-alpha. TNF-alpha is also known by aliases TNF, TNF-SF2, DIF, and Cachectin. |
