Rhesus Monkey TNF Apha Protein

2-1-1-green-tea-extract-1

Rhesus Monkey TNF Apha Protein

Cat. No.: SPODRP00922
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Product Details

Target: TNF alpha (Tumor necrosis factor alpha (TNF-α))
Biological Activity: Active
Protein Type: Recombinant
Origin: Rhesus Monkey
Source: E. coli
Application: Functional studies (Func)
Sequence: VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELTDNQLVV PSEGLYLIYS QVLFKGQGCP SNHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINLPD YLDFAESGQV YFGIIAL
Characteristics: Biological activity: Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.05 ng/mL, corresponding to a specific activity of >2 x 107 IU/mg in the presence of actinomycin D.
Purity: > 95% as determined by SDS-PAGE and HPLC.
Sterility: 0.2 μm filtered
Format: Lyophilized
Buffer: PBS, pH7.4, 5% trehalose.
Storage: - 20°C
Alternative Name: TNF alpha
Synonyms: DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa.
Background: This cytokine binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR receptors, predominantly secreted by macrophages. It possesses the capability to trigger cell death in specific tumor cell lines and acts as a potent pyrogen, inducing fever either directly or by stimulating interleukin-1 secretion. Additionally, it is associated with the onset of cachexia. Under specific circumstances, it can promote cell proliferation and foster cell differentiation. The intracellular domain (ICD) form of TNF induces IL12 production in dendritic cells.
Molecular Weight: 17.3 kDa

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