| Synonym(s): |
Keratinocyte Growth Factor; Fibroblast Growth Factor-7; HBGF-7 |
| Description: |
KGF (FGF-7), a member of the FGF family, is crucial during prenatal development, postnatal growth, and tissue regeneration by stimulating cellular proliferation and differentiation. It specifically acts as a mitogen for epithelial cells and keratinocytes. KGF/FGF-7 signals through the FGFR 2b receptor and plays significant roles in kidney and lung development, as well as in angiogenesis and wound healing processes.
Recombinant Murine KGF (FGF-7) is an 18.8 kDa protein composed of 163 amino acid residues. |
| AA Sequence: |
CNDMSPEQTA TSVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNSYNIMEIR TVAVGIVAIK GVESEYYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHSGG EMFVALNQKG IPVKGKKTKK EQKTAHFLPM AIT |
| Purity: |
≥ 95% by SDS-PAGE gel and HPLC analyses |
| Biological Activity: |
Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.5-5.0 ng/mL |
| Accession Number: |
P36363 |
| Gene ID: |
14178 |
| Endotoxin: |
Endotoxin level is < 0.1 ng/μg of protein (< 1 EU/μg). |
| Crossreactivity: |
Mouse |
| Molecular Weight: |
18.8 kDa |
| Source: |
E.coli |
