| Synonym(s): |
Fibroblast Growth Factor-8; FGF-8b; AIGF; HBGF-8 |
| Description: |
FGF-8 (FGF-8b) is a heparin-binding growth factor within the FGF family. These proteins are pivotal in prenatal development, postnatal growth, and tissue regeneration by promoting cellular proliferation and differentiation. FGF-8 has four known alternate spliced forms: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. Human and murine FGF-8A and B are identical, while human and mouse FGF-8E and F are 98% identical. FGF-8 targets cells expressing FGF receptors, including mammary carcinoma cells.
Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein composed of 194 amino acid residues. |
| Source: |
E.coli |
| Purity: |
≥ 95% by SDS-PAGE gel and HPLC analyses |
| Molecular Weight: |
22.5 kDa |
| Gene ID: |
2253 |
| AA Sequence: |
MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR |
| Biological Activity: |
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is 2.0-4.0 ng/mL |
| Accession Number: |
P55075 |
| Endotoxin: |
Endotoxin level is < 0.1 ng/μg of protein (< 1 EU/μg) |
