| Synonym(s): |
Fibroblast Growth Factor-basic; FGF-2; HBGF-2; Prostatropin |
| Description: |
FGF-basic is one of 23 recognized members within the FGF family. These proteins play pivotal roles in prenatal development, as well as in postnatal growth and tissue regeneration by facilitating cellular proliferation and differentiation. FGF-basic itself is a heparin-binding growth factor devoid of glycosylation, found expressed in various tissues including the brain, pituitary gland, kidney, retina, bone, testes, adrenal gland, liver, monocytes, epithelial cells, and endothelial cells. FGF-basic transmits signals through several receptors: FGFR 1b, 1c, 2c, 3c, and 4. Recombinant Human FGF-basic is a 17.2 kDa protein comprising 154 amino acid residues. |
| Source: |
E.coli |
| Purity: |
≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Molecular Weight: |
17.2 kDa |
| Gene ID: |
2247 |
| Biological Activity: |
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/mL, corresponding to a specific activity of ≥ 1 x 107 units/mg. |
| Accession Number: |
AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS |
| Endotoxin: |
Endotoxin level is < 0.1 ng/μg of protein (< 1 EU/μg) |
| Crossreactivity: |
Alpaca, bacteria, chicken, cow, dog, frog, guinea pig, hamster, horse, human, human + hamster, human + mouse, human + rat, human + virus, monkey, mouse, mouse + chicken, mouse + pig, mouse + rat, pig, rabbit, rat, rat + chicken, sheep |
