| Synonym(s): |
CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor superfamily member 16 antibody |
| Description: |
Rabbit monoclonal [EP1039Y] to p75 NGF Receptor |
| Application: |
Suitable for: WB, IP, IHC-P, ICC/IF, Flow Cyt (Intra) |
| Purity: |
Protein A purified |
| Shipping: |
Shipped at 4°C. |
| Storage: |
Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Storage Buffer: |
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA |
| Species Reactivity: |
Reacts with: mouse, rat, human |
| Immunogen: |
Synthetic peptide within Human p75 NGF Receptor aa 350-450. The exact sequence is proprietary. |
| Specificity: |
The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat. |
| Clonality: |
Monoclonal |
| Clone Number: |
EP1039Y |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Formulation: |
Liquid |
| Positive Control: |
ICC/IF: PC-12 cells. IHC-P: Human tonsil tissue; Mouse uterus tissue. WB: Capan-1, SW80, Neuro-2a and PC-12 cell lysate; Mouse uterus, hippocampus and cerebral cortex lysate; Rat uterus, hippocampus and brain cortex lysate; Human hippocampus and brain cortex lysate. IP: PC-12 cell lysate. Flow Cyt (intra): PC-12 cells. |
| Sequence Similarities: |
Contains 1 death domain
Contains 4 TNFR-Cys repeats |
| Domain: |
Death domain is responsible for interaction with RANBP9.
The extracellular domain is responsible for interaction with NTRK1. |
| Cellular Localization: |
Membrane |
| Dissociation Constant (KD): |
KD = 3.25 × 10-10 M |
| Post-translational Modifications: |
N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues. |
| Function: |
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. |
