| Synonyms: |
DIF, TNF-alpha, TNFA, TNFSF2, RATTNF, Tnfa, tnf, TNF-a, TNFalpha, Tnfsf1a, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, tnfsf2, tnf-alpha, Cachectin, tumor necrosis factor, tumor necrosis factor b (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor a (TNF superfamily, member 2), TNF, Tnf, tnf, tnfb, tnf-alpha, LOC103694380, tnfa. |
| Background: |
TNF-α/TNFSF1A, the prototypical ligand of the TNF superfamily, is a versatile cytokine crucial for regulating inflammation and apoptosis. It is produced by activated macrophages, as well as a variety of other cell types such as T and B cells, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells, and certain tumor cells. |
