| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Rat |
| Detection Method: |
Colorimetric |
| Method Type: |
Sandwich ELISA |
| Sample Type: |
Serum, plasma, cell culture supernatant |
| Sensitivity: |
30 pg/mL |
| Application: |
ELISA |
| Plate: |
Pre-coated |
| Characteristics: |
IL6 ELISA kit (rat) (Interleukin-6, IL-6, B-cell stimulatory factor 2, CTL differentiation factor, CDF, hybridoma growth factor, interferon beta-2, IFN-beta-2, IL6, IFNB2). |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
4°C, - 20°C |
| Alternative Name: |
IL6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Interleukin 6 (IL-6) is a versatile cytokine with pivotal roles in host defense, acute phase reactions, immune responses, neuronal functions, and hematopoiesis. It is expressed by various normal and transformed cells, both lymphoid and non-lymphoid. IL-6 production is stimulated by diverse signals such as mitogens, antigens, lipopolysaccharides, calcium ionophores, cytokines, and viruses. However, IL-4, IL-10, and IL-13 exhibit inhibitory effects on IL-6 expression in monocytes.
Elevated serum levels of IL-6 have been documented in numerous pathological conditions, encompassing bacterial and viral infections, trauma, autoimmune disorders, inflammation, and malignancies. The cDNA of rat IL-6 encodes a precursor polypeptide of 211 amino acid residues, featuring a hydrophobic signal peptide that undergoes cleavage to yield the mature protein comprising 187 amino acids. Notably, at the protein sequence level, there is approximately 39% identity between rat and human IL-6, while there exists an 87% identity between mouse and rat IL-6. |
