| Target: |
IL-6 (Interleukin 6) |
| Biological Activity: |
Active |
| Protein Type: |
Recombinant |
| Origin: |
Rat |
| Source: |
E. coli |
| Sequence: |
FPTSQVRRGD FTEDTTHNRP VYTTSQVGGL ITYVLREIFE MRKELCNGNS DCMNSDDALS ENNLKLPEIQ RNDGCFQTGY NQEICLLKIC SGLLEFRFYL EFVKNNLQDN KKDKARVIQS NTETLVHIFK QEIKDSYKIV LPTPTSNALL MEKLESQKEW LRTKTIQLIL KALEEFLKVT MRSTRQ |
| Characteristics: |
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > units/mg. |
| Purity: |
> 97% by SDS-PAGE and HPLC analyses. |
| Endotoxin Level: |
Level Less than 1EU/µg of rRtIL-6 as determined by LAL method |
| Format: |
Lyophilized |
| Reconstitution: |
Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Storage: |
4°C |
| Alternative Name: |
Interleukin-6 (IL-6) |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
IL-6 is a multifaceted cytokine crucial for host defense, orchestrating immune and inflammatory responses. It is synthesized by various cell types including T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, exhibiting a wide array of biological activities. |
| Molecular Weight: |
21.7 kDa, a single, non-glycosylated polypeptide chain containing 187 amino acids. |
