| Target: |
IL-6 (Interleukin 6) |
| Biological Activity: |
Active |
| Protein Type: |
Recombinant |
| Protein Characteristics: |
Extracellular domain, AA 25-211 |
| Source: |
HEK-293 cells |
| Purification tag / Conjugate: |
This IL-6 protein is labelled with Fc Tag. |
| Application: |
SDS-PAGE (SDS) |
| Cross-Reactivity: |
Mouse (Murine) |
| Characteristics: |
The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2. |
| Purity: |
> 95% (SDS-PAGE) |
| Endotoxin Level: |
< 0.01 EU/μg protein |
| Format: |
Lyophilized |
| Concentration: |
Lot specific |
| Reconstitution: |
Reconstitute with 100 μL sterile water. |
| Buffer: |
Lyophilized. Contains PBS. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Short term storage: + 4°C.
Long term storage: - 20°C Stable for at least 1 year after receipt when stored at - 20°C. Working aliquots are stable for up to 3 months when stored at - 20°C. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL-6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Interleukin 6 (IL-6) is a multifaceted alpha-helical cytokine crucial in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. Its activity is pivotal in the shift from acute inflammation to either acquired immunity or chronic inflammatory diseases. IL-6 is produced by various cell types as a 22 kDa-28 kDa phosphorylated and variably glycosylated molecule. It triggers signaling via a cell surface heterodimeric receptor complex consisting of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 stands as a pivotal factor in plasma cell growth. |
| Molecular Weight: |
50 kDa |
