| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Mouse |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
ELISA, western blotting (WB) |
| Purification: |
Purified |
| Immunogen: |
IL6 antibody was raised in rabbit using highly pure recombinant murine IL-6 as the immunogen. |
| Format: |
Lyophilized |
| Concentration: |
Lot specific |
| Reconstitution: |
Reconstitute in sterile water to a concentration > 0.2 mg/mL. |
| Buffer: |
Lyophilized from PBS, pH7.4. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store at - 20°C until reconstitution. Following reconstitution product may be stored at 4°C in the short term. For long term storage aliquot and freeze at - 20°C. |
| Alternative Name: |
IL6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
IL6 is a multifaceted cytokine pivotal in orchestrating host defense mechanisms through the modulation of immune and inflammatory responses. Generated by an array of cell types including T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, IL6 exhibits diverse biological roles. It fosters B-cell differentiation and enhances antibody production, collaborates with IL3 in megakaryocyte maturation and platelet formation, triggers the synthesis of acute-phase proteins in the liver, and governs bone metabolism. Signaling of IL6 is mediated via the IL6 receptor system, comprising two components: IL6R alpha and gp130. Notably, mouse-derived IL6 remains inert on human cells, whereas both human and mouse versions display equal potency on mouse cells. |
| Molecular Weight: |
21.7 kDa (predicted detection band MW) |
