| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Human |
| Host: |
Goat |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
ELISA, western blotting (WB) |
| Purification: |
Purified |
| Immunogen: |
IL6 antibody was raised in goat using highly pure recombinant human IL-6 as the immunogen. |
| Format: |
Lyophilized |
| Concentration: |
Lot specific |
| Buffer: |
Lyophilized from PBS, pH7.2. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store at - 20°C until reconstitution. Following reconstitution product may be stored at 4°C in the short term. For long term storage aliquot and freeze at - 20°C. |
| Alternative Name: |
IL6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
IL6 is a multifunctional cytokine pivotal in orchestrating host defense mechanisms by modulating immune and inflammatory responses. It emanates from various cell types including T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, showcasing a wide array of biological effects. Its actions span from promoting B-cell differentiation and antibody generation to collaborating with IL3 in the development of megakaryocytes and platelet formation. Moreover, IL6 triggers the synthesis of acute-phase proteins in the liver and governs bone metabolism. Its signaling pathway involves the IL6 receptor system, comprising IL6R alpha and gp130 chains. Notably, while mouse-derived IL6 lacks potency on human cells, both human and mouse variants exhibit comparable activity on mouse cells. |
| Molecular Weight: |
21.7 kDa (predicted detection band MW) |
