| Target: |
IL-6 (Interleukin 6) |
| Binding Specificity: |
AA 195-212 |
| Reactivity: |
Human |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
Western blotting (WB) |
| Purification: |
Antigen affinity |
| Immunogen: |
Amino acids 195-212 (LRSFKEFLQSSLRALRQM) were used as the immunogen for this IL-6 antibody. |
| Isotype: |
IgG |
| Format: |
Liquid |
| Buffer: |
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water. |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
- 20°C |
| Storage Comment: |
After reconstitution, the IL-6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at - 20°C. |
| Alternative Name: |
IL-6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Interleukin-6 (IL-6) is a protein encoded by the IL6 gene in humans. It serves as a dual-functioning cytokine, exhibiting both pro-inflammatory and anti-inflammatory properties. T cells and macrophages secrete IL-6 to initiate immune responses, particularly in cases of trauma like burns or tissue damage that triggers inflammation. IL-6 plays a crucial role in inducing fever and the acute phase response. Additionally, it is vital for the growth of hybridomas and is commonly present in various cloning media formulations such as briclone. Bowcock et al. (1988) localized the IL6 gene to chromosome 7p21, while Sutherland et al. (1988) further pinpointed its location to chromosome 7p15 using in situ hybridization and Southern blot analysis of mouse-human hybrid cell lines. |
