| Target: |
IL-6 (Interleukin 6) |
| Binding Specificity: |
AA 111-150 |
| Reactivity: |
Human, mouse, rat, cow, rabbit |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
ELISA, flow cytometry (FACS), immunofluorescence (cultured cells) (IF (cc)), immunofluorescence (paraffin-embedded sections) (IF (p)), immunohistochemistry (frozen sections) (IHC (fro)), immunohistochemistry (paraffin-embedded Sections) (IHC (p)), western blotting (WB) |
| Purification: |
Purified by protein A. |
| Immunogen: |
KLH conjugated synthetic peptide derived from mouse IL-6. |
| Isotype: |
IgG |
| Format: |
Liquid |
| Concentration: |
1 μg/μL |
| Buffer: |
0.01 M TBS (pH7.4) with 1% BSA, 0.03% proclin300 and 50% glycerol. |
| Precaution of Use: |
This product contains a poisonous and hazardous substance, which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
Store at - 20°C for one year. Avoid repeated freeze/thaw cycles. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL-6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
This cytokine boasts a wide array of biological functions, serving as a potent trigger for the acute phase response. It plays a crucial role in guiding B-cell maturation into Ig-secreting cells and is pivotal in the differentiation of lymphocytes and monocytes. Its influence extends to B-cells, T-cells, hepatocytes, hematopoietic progenitor cells, and CNS cells. Integral for the development of T(H)17 cells, it also functions as a myokine, being released into the bloodstream post-muscle contraction. This release prompts increased fat breakdown and improved insulin resistance. Moreover, it stimulates the growth of myeloma and plasmacytoma and fosters nerve cell differentiation. |
