| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Mouse |
| Host: |
Rat |
| Clonality: |
Monoclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
Immunoassay (IA), neutralization (Neut), western blotting (WB) |
| Sterility: |
0.2 μm filtered |
| Clone: |
MP5-32C11 |
| Format: |
Liquid |
| Buffer: |
PBS, containing 0.1% bovine serum albumin. |
| Handling Advice: |
Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year. |
| Storage: |
4°C |
| Storage Comment: |
Lyophilized product should be stored at 4°C Store stock solution in aliquots at - 20°C. |
| Expiry Date: |
12 months |
| Alternative Name: |
Interleukin 6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
The antibody effectively neutralizes mouse interleukin 6 (IL-6) without exhibiting cross-reactivity with lipopolysaccharide (LPS), TNF-alpha, human IL-6, or rat IL-6 in proliferation assays utilizing the KD83 cell line. MP5-32C11 specifically inhibits mouse IL-6-induced proliferation of the NFS60 myelomonocytic cell line and KD83 plasmacytoma. IL-6, a versatile cytokine weighing between 20-22 kDa, plays a pivotal role in severe infection pathophysiology, immune response modulation, acute phase reaction, and hematopoiesis regulation. Furthermore, IL-6 significantly contributes to B-cell differentiation into plasma cells and acts as a potent growth factor for plasmacytoma and myeloma. Its sustained gene expression is crucial in the multistep oncogenesis of plasma cell neoplasia. IL-6 also serves as a highly beneficial culture supplement for generating a substantial number of antibody-producing hybridomas. |
