| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Human |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
Enzyme immunoassay (EIA), western blotting (WB) |
| Purification: |
Protein G affinity purified |
| Immunogen: |
Purified recombinant human IL-6 |
| Clone: |
2-00E-010 |
| Isotype: |
IgG2a |
| Reconstitution: |
Double distillated water is recommended to reconstitute the antibody. |
| Buffer: |
0.01 M PBS, pH7.2 |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
- 20°C |
| Storage Comment: |
Store (in aliquots) at - 20°C. |
| Alternative Name: |
Interleukin-6 (IL6) |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Interleukin 6 (IL6) is a versatile 24 kDa protein initially identified in the culture medium of RNA-stimulated fibroblastoid cells. Its expression is boosted by various factors like IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, and IL17, while it is suppressed by glucocorticoids, IL4, and TGF beta. IL6 plays a direct role in orchestrating responses following infections and cellular damage, potentially rivaling the significance of IL1 and TNF alpha in regulating the acute phase response. Moreover, IL6 is implicated in modulating adipose tissue mass. It is generated by fibroblasts, activated T cells, monocytes or macrophages, and endothelial cells. Acting on multiple cell types such as fibroblasts, myeloid progenitors, T cells, B cells, and hepatocytes, IL6 is pivotal in numerous physiological processes. Additionally, it collaborates with IL2 in promoting T lymphocyte proliferation and enhances the proliferative effects of IL3 on multipotential hematopoietic progenitors. |
