| Target: |
IL-18 (Interleukin 18) |
| Binding Specificity: |
C-term |
| Reactivity: |
Human, mouse, rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-18 antibody is un-conjugated |
| Application: |
Western blotting (WB) |
| Sequence: |
IIFFQRSVPG HDNKMQFESS SYEGYFLACE KERDLFKLIL KKEDELGDRS |
| Characteristics: |
This is a rabbit polyclonal antibody against IL18. It was validated on Western Blot. |
| Purification: |
Affinity purified |
| Immunogen: |
The immunogen is a synthetic peptide directed towards the C terminal region of human IL18. |
| Format: |
Liquid |
| Concentration: |
Lot specific |
| Buffer: |
Liquid. Purified antibody supplied in 1 x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freeze-thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
For short term use, store at 2 - 8°C up to 1 week. For long term storage, store at - 20°C in small aliquots to prevent freeze-thaw cycles. |
| Alternative Name: |
IL18 |
| Synonyms: |
Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18, interleukin 18, Il18, IL18. |
| Background: |
The gene's protein product acts as a proinflammatory cytokine, capable of triggering IFN-gamma production in T cells. When paired with IL12, it inhibits IL4-dependent IgE and IgG1 production while boosting IgG2a production in B cells. IL-18 binding protein (IL18BP) can directly interact with this cytokine, thereby dampening its biological effects. |
| Molecular Weight: |
18 kDa |
