IL-12 Polyclonal Antibody (AA 168-195)

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IL-12 Polyclonal Antibody (AA 168-195)

Cat. No.: SPODRP00322
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Product Details

Target: IL-12 (Interleukin 12)
Binding Specificity: AA 168-195
Reactivity: Human
Host: Rabbit
Clonality: Polyclonal
Conjugate: This IL12 antibody is un-conjugated
Application: Flow cytometry (FACS), immunohistochemistry (IHC), ELISA, western blotting (WB)
Purification: Antigen affinity purified
Immunogen: A portion of amino acids 168-195 from the human protein was used as the immunogen for this IL-12 antibody.
Isotype: Ig fraction
Format: Liquid
Buffer: In 1X PBS, pH7.4, with 0.09% sodium azide.
Precaution of Use: This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only.
Handling Advice: Avoid repeated freeze-thaw cycles.
Storage: - 20°C
Storage Comment: Aliquot the IL-12 antibody and store frozen at -20 °C or colder.
Alternative Name: IL-12
Synonyms: CLMF, CLMF2, IL-12B, NKSF, NKSF2, p40, Il-12b, Il12p40, Il-12p40, Il12, IL-12p40, IL-12, LOC100217488, IL-12p35, Il-12a, Ll12a, p35, IL12p40, IL12B, IL-12 p35, interleukin 12B, interleukin 12A, interleukin 12b, interleukin 12a, Interleukin 12 level, IL12B, IL12A, Il12b, Il12a, IL12, il12a.
Background: IL12A is a disulfide-linked heterodimer consisting of a 35-kD subunit encoded by IL12A and a 40-kD subunit belonging to the cytokine receptor family. It is essential for the T-cell-independent induction of interferon (IFN)-gamma and plays a crucial role in the differentiation of both Th1 and Th2 cells. The effects of this cytokine on lymphocytes are mediated by the transcription activator STAT4. Additionally, nitric oxide synthase 2A (NOS2A/NOS2) is necessary for this cytokine's signaling in innate immunity.

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