| Target: |
IL-12 (Interleukin 12) |
| Binding Specificity: |
AA 141-200 |
| Reactivity: |
Rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL12 antibody is un-conjugated |
| Application: |
ELISA, immunocytochemistry (ICC), immunofluorescence (cultured cells) (IF (cc)), immunofluorescence (paraffin-embedded sections) (IF (p)), immunohistochemistry (frozen sections) (IHC (fro)), immunohistochemistry (paraffin-embedded sections) (IHC (p)), western blotting (WB) |
| Purification: |
Purified by protein A. |
| Immunogen: |
KLH conjugated synthetic peptide derived from rat IL-12. |
| Isotype: |
IgG |
| Format: |
Liquid |
| Concentration: |
1 μg/μL |
| Buffer: |
0.01 M TBS (pH7.4) with 1% BSA, 0.03% proclin300 and 50% glycerol. |
| Precaution of Use: |
This product contains a poisonous and hazardous substance, which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
Store at - 20°C for one year. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL-12 |
| Synonyms: |
CLMF, CLMF2, IL-12B, NKSF, NKSF2, p40, Il-12b, Il12p40, Il-12p40, Il12, IL-12p40, IL-12, LOC100217488, IL-12p35, Il-12a, Ll12a, p35, IL12p40, IL12B, IL-12 p35, interleukin 12B, interleukin 12A, interleukin 12b, interleukin 12a, Interleukin 12 level, IL12B, IL12A, Il12b, Il12a, IL12, il12a. |
| Background: |
The IL-12 protein is a cytokine mainly produced by monocytes and, to a lesser extent, by lymphocytes. It has diverse roles in immunoregulation and inflammation. IL-12 reduces the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also promotes B cell survival, proliferation, and antibody production. Additionally, IL-12 can inhibit NF-kappa B activity and is involved in regulating the JAK-STAT signaling pathway. |
