| Target: |
IFNB1 (Interferon, beta 1, Fibroblast) |
| Binding Specificity: |
N-Term |
| Reactivity: |
Human |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IFNB1 antibody is un-conjugated |
| Application: |
Enzyme immunoassay (EIA), western blotting (WB) |
| Specificity: |
This antibody reacts to IFNB1. |
| Purification: |
Affinity chromatography on protein A. |
| Immunogen: |
KLH conjugated synthetic peptide selected from the N-terminal region of human Interferon beta 1/IFNB1. |
| Format: |
Liquid |
| Concentration: |
0.25 mg/mL |
| Buffer: |
PBS containing 0.09% (W/V) sodium azide as preservative. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store the antibody undiluted at 2 - 8°C for one month or (in aliquots) at - 20°C for longer. |
| Alternative Name: |
IFNB / Interferon beta |
| Synonyms: |
IFB, IFF, IFNB, IFN-beta, Ifb, Ifnb, IFNb, interferon beta 1, interferon beta 1, fibroblast, interferon, beta 1, fibroblast, IFNB1, Ifnb1. |
| Background: |
Mammalian type I Interferons (IFN1) are produced in response to viral infection and other stimuli. They consist of alpha and beta subtypes with varying reactivity in leukocytes and fibroblasts. Human IFN alphas, encoded by a family of at least 15 genes, and IFN beta, the sole member of its subtype, share approximately 50% amino acid homology. Both IFN subtypes are pleiotropic cytokines with similar biological activities, but differ in potency and cell type-specific effects. IFN beta exhibits a stronger antiproliferative response in certain cell types such as embryonal carcinoma, melanoma, and melanocytes compared to IFN alphas. It shows higher efficacy in treating multiple sclerosis and some cancers. Type I IFNs signal through a common cell surface receptor comprising IFNAR1 and IFNAR2 chains, both essential for high-affinity binding and biological activity. Tyrosine kinases Jak1 and Tyk2, part of the Janus kinase family, bind to the intracellular portions of the receptor subunits. Upon ligand binding, these kinases activate and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2. |
