| Target: |
IFNB1 (Interferon, beta 1, Fibroblast) |
| Binding Specificity: |
Middle Region |
| Reactivity: |
Human, Mouse |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IFNB1 antibody is un-conjugated |
| Application: |
Immunohistochemistry (paraffin-embedded sections) (IHC (p)), western blotting (WB) |
| Specificity: |
This antibody recognises interferon beta (IFN-beta), a 22 kDa member of the type I alpha/beta interferon family. |
| Purification: |
Purified |
| Immunogen: |
A 17 amino acid peptide located near the centre of human Interferon beta. |
| Isotype: |
IgG |
| Concentration: |
1.0 mg/mL |
| Buffer: |
PBS, 0.02% sodium azide. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store the antibody undiluted at 2 - 8°C for up to one month or (in aliquots) at - 20°C for longer. |
| Alternative Name: |
IFNB / Interferon beta |
| Synonyms: |
IFB, IFF, IFNB, IFN-beta, Ifb, Ifnb, IFNb, interferon beta 1, interferon beta 1, fibroblast, interferon, beta 1, fibroblast, IFNB1, Ifnb1. |
| Background: |
Mammalian type I Interferons (IFN1) are produced in response to viral infection and other stimuli, divided into alpha and beta subtypes based on leukocyte and fibroblast reactivity. Human IFN alphas are encoded by a family of at least 15 genes, while IFN beta stands as the unique member of its subtype. There's around 50% amino acid homology between alpha and beta subtypes, sharing similar pleiotropic cytokine properties and biological activities. IFN subtypes vary in potency and cell-specific activities, with IFN beta showing higher antiproliferative effects in certain cells like embryonal carcinoma, melanoma, and melanocytes compared to IFN alphas. IFN beta demonstrates increased efficacy in treating multiple sclerosis and certain cancers. Type I IFNs signal through a common cell surface receptor composed of IFNAR1 and IFNAR2 chains, both essential for high-affinity binding and biological activity. Intracellularly, tyrosine kinases Jak1 and Tyk2, members of the Janus kinase family, bind to the receptor subunits and become activated upon ligand binding, phosphorylating STAT transcription factors as well as IFNAR1 and 2. |
