| Target: |
IFNA (Interferon alpha) |
| Reactivity: |
Chicken |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Conjugate: |
This IFNA antibody is un-conjugated |
| Application: |
Enzyme immunoassay (EIA), western blotting (WB) |
| Purification: |
Affinity chromatography on protein G. |
| Immunogen: |
Recombinant chicken interferon alpha |
| Clone: |
UMCh3-IFN-a |
| Isotype: |
IgG1 |
| Concentration: |
0.5 mg/mL |
| Buffer: |
PBS containing 0.09% sodium azide. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store the antibody undiluted at 2 - 8°C for one month or (in aliquots) at - 20°C for longer. |
| Alternative Name: |
Interferon alpha (IFN Alpha) |
| Background: |
The categorization of mammalian cytokines possessing antiviral properties is extensively documented, primarily as Type I Interferon (IFNI) or Type II Interferon (IFNII). However, this classification doesn't directly apply to avian interferons, despite their initial discovery in chickens. Recent functional studies are revealing similarities between chicken interferon and mammalian IFNI, highlighting the conservation of cysteine residues and the presence of approximately ten closely related intron-less IFN alpha genes. Further investigation has demonstrated robust expression of chicken IFN-alpha genes following viral infection in monocyte-derived macrophages and embryo fibroblasts, with recombinant chicken IFN proving to be a potent antiviral agent. |
