| Target: |
IFNA (Interferon alpha) |
| Reactivity: |
Human |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Conjugate: |
This IFNA antibody is un-conjugated |
| Application: |
ELISA |
| Characteristics: |
This mAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 interferon- & receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of serine 535 and 539 in the IFNAR1. |
| Purification: |
Protein G affinity chromatography |
| Immunogen: |
Purified recombinant human IFNA1 was used as the immunogen for the Interferon alpha antibody. |
| Clone: |
2-52 |
| Isotype: |
IgG1 kappa |
| Concentration: |
1 mg/mL |
| Buffer: |
1 mg/mL in 1X PBS, BSA free, sodium azide free. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
Store the Interferon alpha antibody at 2 - 8°C (with azide) or aliquot and store at - 20°C or colder (without azide). |
| Alternative Name: |
Interferon alpha |
| Background: |
This monoclonal antibody (mAb) specifically targets human interferon alpha 1 and shows no cross-reactivity with human interferon alpha 2. Interferons are widely employed therapeutically due to their anti-tumor and anti-viral properties, as well as their regulatory effects on the immune system. These cytokines exert their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). The modulation of cytokine signaling magnitude and duration is largely governed by the downregulation of this receptor. Such downregulation is influenced by the phosphorylation of Serine 535 and 539 residues within the IFNAR1 protein. |
