| Target: |
IL-6 (Interleukin 6) |
| Biological Activity: |
Active |
| Protein Type: |
Recombinant |
| Protein Characteristics: |
AA 29-212 |
| Origin: |
Human |
| Source: |
CHO cells |
| Characteristics: |
ED50 < 0.06 ng/mL, measured in a cell proliferation assay using 7TD1 cells. |
| Purity: |
> 95% as analyzed by SDS-PAGE and HPLC. |
| Endotoxin Level: |
< 0.2 EU/μg, determined by LAL method. |
| Format: |
Lyophilized |
| Reconstitution: |
Reconstituted in ddH2O or PBS at 100 μg/mL. |
| Buffer: |
Lyophilized after extensive dialysis against PBS. |
| Storage: |
- 80°C |
| Storage Comment: |
Lyophilized recombinant human interleukin-6 remains stable up to 6 months at - 80°C from date of receipt. Upon reconstitution, human interleukin-6 should be stable up to 1 week at 4°C or up to 2 months at - 20°C. |
| Expiry Date: |
6 months |
| Alternative Name: |
Interleukin-6 (IL-6) |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Interleukin-6 (IL-6), alternatively known as BSF-2, CDF, and IFNB2, is a versatile cytokine with roles in both inflammatory and anti-inflammatory processes. Primarily synthesized by T cells, macrophages, monocytes, endothelial cells, and muscle cells, IL-6 interacts with the IL-6 receptor (IL-6R), initiating a cascade where IL-6R associates with gp130, thereby activating signal transduction pathways involving JAKs and STATs. The functions of IL-6 span various biological activities, including the stimulation of B cell differentiation and antibody production, facilitation of myeloma and plasmacytoma proliferation, and promotion of nerve cell differentiation. |
| Molecular Weight: |
21-23 kDa, observed by reducing SDS-PAGE. |
